Program Overview

HER2 testing is an integral part of the standard of care for breast cancer; it not only provides an indication of prognosis, but also more importantly indicates likely response to HER2 targeted therapy. Therefore, as part of the standard of care for breast cancer, HER2 status should be assessed and used to direct therapy. However, several tests are available each with different strengths and weaknesses. While many of the shortcomings can be addressed through the application of good laboratory practice, controversy remains regarding the relative role of IHC and FISH, and the scoring and interpretation of the results. This program will review the most recent data, critique the ASCO/CAP guidelines and discuss the practical application of HER2 testing and provide recommendations which are relevant to everyday clinical practice.

Target Audience

The educational design of these activities addresses the needs of clinicians and nurses involved in the treatment of patients with breast cancer.

For information about the accreditation of this program

Please contact Global at Tel: (303) 395-1782 or inquire@globaleducationgroup.com.

 

Date of Activity: April 22, 2011

     

This activity is jointly sponsored by Global Education Group and Strategic Consultants International

This activity is supported by an educational grant from Genentech.

Educational Objectives

After completing this activity, the participant should be better able to:

  • State the ASCO/CAP Guidelines for HER2 testing
  • Review the criteria laboratories reporting HER2 results should adhere to
  • Explain why samples may have intermediate HER2 status by IHC or FISH and the recommendations for further testing
  • Describe appropriate treatment interventions for breast cancer according to HER2 status, including those with intermediate findings on pathology.

Faculty

William Gradishar William J. Gradishar, MD, FACP  - View Biography                             
Professor of Medicine
Division of Hematology/Oncology
Northwestern Medical Faculty Foundation
Northwestern University Medical School
Feinberg School of Medicine
Chicago, IL
Michael Press Michael F. Press, MD, PhD - View Biography
Professor of Pathology
Norris Comprehensive Cancer Center
(University of South California)
Los Angeles, CA
Jeffrey Ross Jeffrey S. Ross, MD - View Biography
Cyrus Strong Merrill Professor and Chair
Department of Pathology and Laboratory Medicine
Albany Medical College
Albany, NY

Disclosure of Conflicts of Interest

Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Faculty or Presenter

Reported Financial Relationship

William J. Gradishar, MD, FACP

Nothing to disclose

Michael F. Press, MD, PhD

Consultant Independent Contractor
Sanofi Aventis
GlaxoSmithKline (GSK)
Grant Research Support
Genentech, Inc.
GSK (institution)
Ventana Med Systems

Jeffrey S. Ross, MD

Consultant Independent Contractor
Foundation Medicine, Inc.
GenPath BRL
Dako
Speaker’s Bureau
Genentech, Inc.
Grant Research Support
Foundation Medicine, Inc.
Honoraria
Genentech, Inc.
Stock Shareholder
Foundation Medicine, Inc.
Syfr, Inc.
Other/Royalties
Various textbooks

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to this content of this CME activity:

Name of Planner or Manager

Reported Financial Relationship

Jackie Dawson, MSN

Nothing to disclose

Amanda Glazar, PhD

Nothing to disclose

Ian Morgan, MSc

Nothing to disclose